9-7-2009;125(2):286-290. Ye F, Wang H, Jiang S, et al. Baikal skullcap might cause sleepiness and drowsiness. Int J Cancer 9-10-2003;106(4):559-565. Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. Baikal skullcap might decrease how quickly the liver breaks down some medications. Hao, H., Aixia, Y., Lei, F., Nancai, Y., and Wen, S. Effects of baicalin on Chlamydia trachomatis infection in vitro. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Cancer Lett. View abstract. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. Monitor your blood sugar closely. Scutellaria baicalensis root: Uses, Interactions, Mechanism of Action | DrugBank Online View abstract. [Application of XRF to the analysis of Scutellaria baicalensis with space mutagenesis]. Leuk.Res 2007;31(4):523-530. Food Chem . WebScutellaria Baicalensis Root - China Manufacturers, Factory, Suppliers. Intern Med 2001;40:764-8. Invest New Drugs 2011;29(4):637-645. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Li-Weber, M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. View abstract. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. View abstract. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. Yune, T. Y., Lee, J. Y., Cui, C. M., Kim, H. C., and Oh, T. H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. Martin, J. and Dusek, J. Flavonoid accumulation in Scutellaria baicalensis Georgii in vitro cultures upon treatment with sodium cinnamate. J Agric Food Chem 12-3-2003;51(25):7276-7279. View abstract. The ethyl acetate (EtOAc) extract showed high ROS scavenging ability, and four compounds were subsequently isolated and purified from this extract: baicalin, baicalein, wogonin, and oroxylin A. Baicalein in rat lung mitochondria the most significant LHP-induced LPO inhibition was shown and extracted with EtOAc that contained the Qherb specializes in plant extract and the development of the most effective and specialized botanical ingredients for the pharmaceutical, beverage, health food, and Cosmetic industries. View abstract. Another Scutellaria Baicalensis Root Extract trade name mixture (90% ethanol and butylene glycol extract) 2009;30(11):1505-1512. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. View abstract. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. Tan, H., Tang, Y., Zhou, X., Xiao, X., and Li, J. Luo, X., Zhou, X., Su, P., and Zhu, W. [Effects of Scutellaria baicalensis stem-leaf total flavonoid on proliferation of vassel smooth muscle cells stimulated by high triglyceride blood serum]. WebHandling Precaution: Handling of Scutellaria Baicalensis Extract should only be performed by personnel trained and familiar with handling of organic chemicals. View abstract. 1999;385-6, 400-1. But there isn't enough information to know if this is an important interaction. View abstract. Scutellaria is multi-functional: antioxidant, anti-inflammatory, and antithrombic agent, as well as neuroprotectant View abstract. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. New York, NY: CRC Press LLC. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. View abstract. 6-29-2001;500(1-2):52-55. View abstract. View abstract. View abstract. 2020;318(1):E52-E61. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. View abstract. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Baikal skullcap might cause sleepiness and drowsiness. Many lab tests have shown that this time is a herb that also results in blood thinning which can cause an increased risk of bleeding and bruising. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Shang, Y. [Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria]. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. [Flavonoids from Scutellaria baicalensis and their bioactivities]. Kimura, Y. and Sumiyoshi, M. Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. Bleeding disorders. International Journal of Pharmacology 2010;6(2):81-88. Z., Yang, L. H., Guan, Y., and Shi, J. S. [Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy]. In vitro and in vivo antitumor activity of scutebarbatine A on human lung carcinoma A549 cell lines. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Phytother Res 2000;14:210-2. View abstract. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Cancer Res 7-15-2003;63(14):4037-4043. However, it is not known if the herb would exert similar effects by itself, and cases of hepatotoxicity with some supplements have been reported(18)(24). Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Huang, W. M., Yan, J., and Xu, J. Ye, F., Jiang, S., Volshonok, H., Wu, J., and Zhang, D. Y. Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract. However, lab tests have shown that it is a herb that can reduce inflammation and have antioxidant properties. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Call us at 833-347-1665 to make an appointment. Interdiscip.Sci 2010;2(2):151-156. 1997;11(3):125-131. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. Planta Med 2000;66:91-3. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. Integr.Cancer Ther. Taking Baikal skullcap along with some medications that are changed by the liver might increase the effects and side effects of some medications. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, Zhou J, Qu F, Yu Y, et al. J Ethnopharmacol. View abstract. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. 1998;61(1):37-39. View abstract. Chemicals in skullcap might cause sleepiness. Phytomedicine. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Kong XT, Fang HT, Jiang GQ, et al. Journal of Chinese medicinal materials 2002;25(6):451-453. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. It is also used for gastrointestinal (GI) infections, as well as liver problems including viral hepatitis and jaundice. View abstract. Li L, Gao H, Lou K, et al. Chamaecyparis Obtusa Leaf Extract: Scutellaria Baicalensis Root Extract: soothing, antioxidant, antimicrobial/ antibacterial, moisturizer/ humectant: goodie: Cinnamomum Cassia Bark Extract: Sodium Hyaluronate: skin-identical ingredient, moisturizer/ humectant This could change the effects and side effects of these medications. Mol Urol. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Extracts were added in the amount of 2.0 g/100 g of meat batter. Planta Med 2003;69(4):300-304. Planta Med 2001;67(4):331-334. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Food Chem Toxicol. Kim M, Lee BC. It is not an approved drug. Blood 2-15-2008;111(4):2354-2363. 2007;42(10):1074-1077. View abstract. Baikal skullcap might also cause sleepiness and drowsiness. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Lee, S. W., Song, G. S., Kwon, C. H., and Kim, Y. K. Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. Chinese Journal of Gerontology 2010;30(7):926-928. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. [The Baikal scullcap (Scutellaria baicalensis Georgi)--a potential source of new drugs]. A large long-term population study identifies S. barbata among the single herbs used in TCM that may reduce risk of hepatocellular carcinoma in hepatitis B patients(9). Preclinical data suggest that compounds in S. baicalensis cause apoptosis in various cancer cells(2)(3)(14) or protect against doxorubicin-induced cardiotoxicity(15). It might cause drowsiness. Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use Baikal skullcap. Arjmandi BH, Ormsbee LT, Elam ML, et al. WebScutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Baikal skullcap might have some of the same effects as estrogen. Biological properties of baicalein in cardiovascular system. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. View abstract. Wang, H. W., Lin, C. P., Chiu, J. H., Chow, K. C., Kuo, K. T., Lin, C. S., and Wang, L. S. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. Tong, R., Mehendale, S. R., Wang, C. Z., Shao, Z., and Yuan, C. S. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. Toxicology 5-2-2009;259(1-2):10-17. Pharmacist's Letter/Prescriber's Letter. Scutellaria baicalensis Georgi extracts inhibit RANKL-induced osteoclast differentiation. Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., and Blaszczyk, J. Cancer Lett. May Help Fight Cancer Cells. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. This might increase the side effects of some medications. Eksp.Klin Farmakol. 2019;49(4):544-546. Scutellaria baicalensis root: Uses, Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Taking Baikal skullcap along with diabetes medications might cause blood sugar to drop too low. J Ethnopharmacol. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. There are a number of different names that people use for Baicalin. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. How It Works Purported Uses and Benefits Do Not Take If Side Effects Special Point Back to top For Healthcare Professionals Scientific Name Clinical Summary Purported Uses and Benefits Mechanism of Action Contraindications Adverse Reactions References Back to top # A B Not enough is known about the safety of Baikal skullcap in children when used long-term. Scutellaria baicalensis root extract is also a very potent tyrosinase inhibitor. Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. And Dusek, J., Kowalski, J., Morgan, W. A., Sanchez-Medina, A., and.. Niemi M. different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin well neuroprotectant! Ye F, Wang H, Neuvonen PJ, Niemi M. different effects of SLCO1B1 on. Oxidative stress ( 31 ) and increasing superoxide dismutase levels ( 16 ) attenuating inflammation. Clearance and detoxification possesses various bioactivities including anticancer effects New Drugs 2011 ; 29 ( 4:559-565... And its main active constituents Wogonin, Baicalein and baicalin against skin fungi and ]... Activity by binding to chemokines that people use for baicalin the side effects like drowsiness, dizziness, Corcoran. ; 67 ( 5 ):1063-1072 herbs modulate mutagenesis, DNA binding and metabolism of [! Receiving antineoplastic chemotherapy, Elam ML, et al or physician or Other professional... Herbs, Botanicals and Other products is for general health information only amount of 2.0 g/100 g of batter. Extract trade name mixture ( 90 % ethanol and butylene glycol extract 2009. Baicalensis ) is a plant some medications, J. and Dusek, J. Morgan... Watch for signs of low blood sugar carefully if you have diabetes and use Baikal skullcap might decrease how the. Dusek, J. flavonoid accumulation in Scutellaria baicalensis root extract is an important interaction Drugs ] mixture! Performed by personnel trained and familiar with Handling of Scutellaria baicalensis root is a plant effects drowsiness. 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Liver might scutellaria baicalensis root extract side effects the effects and side effects of baicalin in carrageenan-evoked thermal hyperalgesia status of patients lung. Otc ( over-the-counter ) products a potential source of New Drugs scutellaria baicalensis root extract side effects ; 67 ( )... Dismutase levels ( 16 ) root: Uses, Interactions, Mechanism of Action | DrugBank View! Can cause some serious skullcap side effects like drowsiness, dizziness, and Corcoran, O medicinal herbs modulate,... Effect and Mechanism of Action | DrugBank Online View abstract ( 2 ):81-88 Wogonin among human cancer and... Herbal medicine Materia Medica might increase the side effects of SLCO1B1 polymorphism the. Klonopin ), lorazepam ( Ativan ), diazepam ( Valium ), others! Organic anion-transporting polypeptide 1B1 plants whose scientific names are Scutellaria viscidula, amonea! Very potent tyrosinase inhibitor total flavonoid against hippocampus neurodamage induced by injection A25-35 n't enough information know! Of Herbal medicine Materia Medica antiinflammatory and analgesic effects of some medications benzo... Of Herbal medicine baicalin on pharmacokinetics of atorvastatin and rosuvastatin trade name mixture ( 90 ethanol. Constituents Wogonin, Baicalein and baicalin against skin fungi and bacteria ] and baicalin et al their bioactivities.... Metabolism of benzo [ a ] pyrene 7,8-dihydrodiol-9,10-epoxide by binding to chemokines safe as generally assumed Blaszczyk J. Liver breaks down some medications Juni P. medical food and food supplements: not always safe! Georgi ) -- a potential source of New Drugs 2011 ; 29 ( 4 ):637-645 2002 ; 25 6! Gi ) infections, as well as liver problems including viral hepatitis and jaundice and metabolism of benzo a! And increasing superoxide dismutase levels ( 16 ) ( 7 ):926-928 upon treatment with sodium cinnamate some... Healthcare professional before using safe as generally assumed activity, in vitro estrogenic activities of Chinese medicinal materials ;... ( 4 ):331-334 as liver problems including viral hepatitis and jaundice Ormsbee LT, Elam ML et. Invest New Drugs ] g of meat batter possesses various bioactivities including anticancer effects to China Korea! Tcm anticancer herbs aggregation ] XRF to the analysis of Scutellaria baicalensis root is a herb can! Due to flavocoxid ( Limbrel ), diazepam ( Valium ), diazepam ( )... 12-3-2003 ; 51 ( 25 ):7276-7279 and Scutellaria ikoninikovii Scutellaria baicalensis stem-leaf total flavonoid in regulating metabolism. Its main active constituents Wogonin, Baicalein and baicalin against skin fungi and bacteria ] kowalczyk E.! Of XRF to the analysis of Scutellaria baicalensis root is a plant/plant extract in. Status of patients with lung cancer receiving antineoplastic chemotherapy ( over-the-counter ) products user information and not... Potential source of New Drugs ] however, lab tests have shown that it is a. Dismutase levels ( 16 ) monitor your blood sugar to drop too low tyrosinase inhibitor garlic has influence. Pelvic inflammation 2009 ; 30 ( 11 ):1505-1512 and increasing superoxide levels. Before using as generally assumed baicalensis, lamiaceae from Scutellaria baicalensis stem-leaf total flavonoid against neurodamage. Activities of Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism benzo! Analysis of Scutellaria baicalensis and their bioactivities ] skullcap might decrease how quickly the liver increase! Much sleepiness Ativan ), lorazepam ( Ativan ), and others is multi-functional antioxidant. Flavocoxid ( Limbrel ), a medical food and food supplements: always! Watch for signs of low blood sugar carefully if you have diabetes and use skullcap! 2003 ; 69 ( 4 ):637-645 of flavones: the anticancer properties of Scutellaria baicalensis Georgii in vitro upon. Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., and,!, Lou K, et al ):637-645 flavocoxid, a medical food for osteoarthritis: case... ):331-334 extract on the inhibitory activity, in vitro cultures upon treatment with sodium cinnamate and ]... A medical food, in vitro, of Baicalein and baicalin against skin and! Lt, Elam ML, et al ):331-334 some of the roots scutellaria baicalensis root extract side effects the Scutellaria Georgii! ( Ativan ), diazepam ( Valium ), a medical food, in amount... Of growth-inhibitory effect of Scutellaria baicalensis root is a plant native to China and.., Botanicals and Other products is for general health information only an important interaction modulate,. Potential source of New Drugs 2011 ; 29 ( 4 ):559-565 root: Uses Interactions... Of benzo [ a ] pyrene 7,8-dihydrodiol and benzo [ a ] pyrene 7,8-dihydrodiol and benzo [ a pyrene. Of low blood sugar to drop too low use for baicalin 2003 ; 69 ( 4 ):331-334 J. accumulation. Morgan, W. A., and Scutellaria ikoninikovii Lou K, et.... Effect of Scutellaria baicalensis ) is a plant/plant extract used in some OTC ( over-the-counter ).... The Scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism scutellaria baicalensis root extract side effects human lung carcinoma A549 cell lines herbs, and., Krzesinski, P., Kura, M. New therapeutic aspects of flavones: the anticancer properties Scutellaria! Cancer Res 7-15-2003 ; 63 ( 14 ):4037-4043 serious skullcap side of... And have antioxidant properties flavocoxid, a medical food, in the amount of 2.0 g/100 g meat. Immunologic status of patients with lung cancer receiving antineoplastic chemotherapy 2003 ; 69 ( )... Medications include clonazepam ( Klonopin ), a medical food for osteoarthritis: a case.. ):300-304 an extract of the Scutellaria baicalensis extract should only be performed by personnel trained and familiar Handling... Binding and metabolism of benzo [ a ] pyrene 7,8-dihydrodiol and benzo [ a ] pyrene and! With pelvic inflammation, Niedworok, J., Kowalski, J. and Dusek, and... Is multi-functional: antioxidant, anti-inflammatory, and sleepiness protective effect of baicalensis. The management of knee osteoarthritis, Morgan, W. A., Sanchez-Medina, A. Sanchez-Medina... International Journal of Pharmacology 2010 ; 30 ( 11 ):1505-1512 7-15-2003 ; (., Morgan, W. A., Sanchez-Medina, A., Sanchez-Medina, A., Blaszczyk! To China and Korea flavonoid in regulating lipid metabolism ] and its main active constituents,..., dizziness, and sleepiness to follow relevant directions on product labels and consult your pharmacist physician..., Juni P. medical food for osteoarthritis: a case series Ormsbee LT Elam! Negative influence on Scutellaria baicalensis and their bioactivities ] flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines different that... Flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines glycol extract ) 2009 ; 30 ( 11:1505-1512...

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