Magnolia. Active constituents in magnolia bark have shown in laboratory studies to have anti-tumor effects, and promote the death of cancerous cells. Stress is defined as a state of mental or emotional strain caused by adverse circumstances. Worley S. L. (2018). Journal of the International Society of Sports Nutrition, 10(1), 37. https://doi.org/10.1186/1550-2783-10-37, Tian, H., Zhao, L., Zhang, Q., Zhang, Y., Mao, X., Wang, J., Li, T., Li, J., You, Z., Ruan, Q., & Jiang, L. (2020). Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. The magnolia extract improved health issues such as anxiety, insomnia, depression, and libido. While we may never completely eradicate cancer from this world, groundbreaking discoveries have the potential to give us the upper hand against this aggressive disease. Hospital affiliations include Hoag Memorial Hospital Presbyterian. Cincinnati, OH: Ohio Valley Co. Retrieved from: https://www.henriettes-herb.com/eclectic/cook/MAGNOLIA_GLAUCA.htm. Privacy Policy. Cancer acts with innate intelligence, like it has a mind of its own, and uses sophisticated mechanisms to survive at any cost. These two compounds come under the category of polyphenols plant micronutrients that offer health benefits like defense against UV radiation and microbial infection.. In a clinical trial involving healthy, overweight, premenopausal women, Magnolia officinalis extract (MOE) demonstrated a weight loss effect on those that overate when they were stressed. The women experienced significant improvements in insomnia, anxiety, mood, and irritability (31). Today, magnolia bark extract is readily available in pill form. When the danger passes, the system turns off and resets. What if we could use our minds to reduce galectin-3? Both independent doses were not as effective in shrinking the tumor as the combination dose. or Healthy Lifestyle Brands. All of this makes it all the more important to explore natural ways to relieve stress. Along with these health benefits, the bark also has strong potential for weight loss, reducing inflammation, and improving sleep. Not recommended for use during pregnancy and breastfeeding due to lack of data and evidence. The American journal of Chinese medicine, 41(3), 531544. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Magnolia bark is a popular herb used for gut health and stress-induced anxiety. A 2018 review of 44 articles on the safety and toxicity of the honokiol and magnolol compounds in magnolia bark determined that the substances are safe for human consumption (1). BioMed research international, 2021, 6688414. https://doi.org/10.1155/2021/6688414, Wang, Y. D., Sun, X. J., Yang, W. J., Li, J., & Yin, J. J. Doing so may cause drowsiness and make it unsafe for you to drive or use heavy machinery., Alternative Therapies in Health and Medicine: Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial., Current Microbiology: The Therapeutic Effects ofMagnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice., Institute for Traditional Medicine: MAGNOLIA BARK., Journal of the International Society of Sports Nutrition: Effect ofMagnolia officinalis andPhellodendron amurense (Relora) on cortisol and psychological mood state in moderately stressed subjects., Journal of Zhejiang University. All rights reserved. Many of its traditional uses have been scientifically tested (via animal and in vitro trials) and show promising results. If you decide to take magnolia bark, carefully read the manufacturers instructions to know how much to take and how often. I recently got some mulungu extract which I heard is the ultimate anxiety reducer but still waiting to try it because even taking a new supplement is anxiety inducing haha. Thats when survival mode transforms into a threat on its own. Corticosterone and serotonin each play a role in regulating anxiety, mood, and depression. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. The goal is to create a multifaceted strategy that targets cancers multiple survival mechanisms with diverse, synergistic treatments. 2023 Dr. Axe. Magnolia bark has been known to have a wide therapeutic scope, being especially supportive for anxiety and stress, and gastrointestinal issues. (2020). It should be noted that results improved when dose size increased. Magnolia bark is the bark of the Magnolia tree which is part of the Magnoliaceae family. More than 200 types of magnolia trees exist worldwide. Getting adequate amounts of deep sleep is key for mental and physical health. Taking even 10 minutes in nature can lift your mood and reduce your stress level. Oxidative stress also appears to play a significant role in many changes in the body and mind that accompany aging (11). The soy isoflavones were more effective for hot flashes, vaginal dryness, nocturnal sweating, and palpitations [R, R]. A study in 40 women ages 2050 found that taking 250 mg of magnolia and phellodendron bark extract 3 times a day resulted in greater relief of short-term and temporary anxiety than taking a placebo (24). The herb combination reduced salivary cortisol, a marker of stress, by 18% in comparison to the placebo. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Consider alternative sleep herbs that are harvested in a more sustainable manner. The Therapeutic Effects of Magnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice. It also helps reduce brain inflammation, which has been closely linked with depression, anxiety, and other mood disorders. The berberine in phellodendron might lower blood sugar and. Retrieved from: https://botanical.com/botanical/mgmh/m/magnol03.html#oth, Hobbs, C, Ph.D., L.Ac., AHG. Before supplementing with magnolia bark, check with your medical provider to discuss proper dosage levels and ensure theres no risk of potential interactions with any medications youre taking. He is a respected formulator, clinician, researcher, author and educator. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Grandchildren are some of lifes greatest treasures. Magnolia bark has a sedative effect on the body and has been used to promote sleep and ease anxiety. Magnolia bark continues to be used in dietary supplements today, marketed for potential benefits like reducing stress, decreasing inflammation, and as a natural sleep aid. This article reviews the, Sorrel, which refers to both a leafy green plant and its fruit, is known for its tart taste and powerful health benefits. In fact, eye-opening research shows a direct link between galectin-3 and depression, making this alarm protein a strong potential target in treating stress-related mental illness. Some researchers believe that these effects are due to honokiol, a natural compound in the bark. Nevertheless, amid the wide range of personalized treatments, there remain a handful of powerful integrative therapies that continue to demonstrate remarkableresults against cancer, regardless of the type or stage. The buildup of fat around the liver is among the major causes of liver failure due to various reasons. Grieve, M. (1931). Dietary Supplementation With Magnolia Bark Extract Alters Chicken Intestinal Metabolite Levels. It may also possess anti-cancer effects in higher doses. Traditional Chinese Medicine (TCM) is an ancient form of healthcare that dates the guardian of the tumor microenvironment, Amitabha Medical Clinic and Healing Center, Frankincense Essential Oil Uses and Benefits for Healing, Oregano Oil Benefits for Infections, Fungus & Even the Common Cold, L-Glutamine Benefits Leaky Gut & Metabolism, Secret Detox Drink Recipe (A Natural Detox Drink Recipe), Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Symptoms of Candida Overgrowth & How to Get Rid of It, Investing in Your Grandkids Future? There are many different methods and techniques, so keep trying until you find a practice you feel good about. Thats why you probably feel sick when youre stressed out. In a sleep study, honokiol was able to shorten the time it took for mice to fall asleep and increased the amount of time spent asleep. Anticancer research, 30(3), 777783. Stress comes at you all day, from every angle, now more than ever. There are so many ways that chronic stress harms your body, mind, and mood. Further, noted herbalist Maria Nol Groves, mentions magnolia bark as a helpful herb for reducing nighttime sleep disturbances. And while not every patient will become a miracle, every patient has the potential to be, based on the power of our innate healing capacity. 2023 Healthline Media LLC. Borgonetti, V., Governa, P., Manetti, F., Miraldi, E., Biagi, M., & Galeotti, N. (2021). The safest way to get magnesium is by eating a diet filled with magnesium-rich foods. For example, Apheresis provides critical benefits when used prior to chemotherapy, enhancing chemos efficacy and reducing side effects. Therefore, as long as magnolia bark is used responsibly, there do not appear to be many risks associated with its use. Treasure Island (FL): StatPearls Publishing. Although there isnt much historical information on the magnolia tree and magnolia bark in Asia, there were sightings of the tree in North Carolina as early as the 16th century. Essentially, cancer is using it for its own independent survival within our bodies. Some chemicals in phellodendron might reduce redness and swelling. Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement. Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice. Stay up to date Let me show you"- so instead of ending his life, The REAL Bark team began it. are clickable links to medically peer-reviewed studies. Magnolia bark is a popular herb in traditional Chinese and Japanese medicine. When we block the activity of unhealthy galectin-3 in the body, we can halt and reverse tumor growth, reduce metastasis, and restore proper immune function against the cancer. When we address unhealthy galectin-3 expression with proven methods, we effectively treat not just cancer, but numerous life-threatening conditions as well. $7.77 ($0.13/Count) In Stock. Magnolia helps in preventing fat from building up around the liver. Magnolia Bark. Exception of use under qualified healthcare practitioner supervision. Video: Why You Need Zinc and Where to Find It. In an animal trial, researchers used an isolated active constituent of magnolia bark, honokiol, to test its anxiolytic effects on stressed mice. Magnolia bark ( Houpu) is a traditional Chinese herb that has been used to aid sleep for thousands of years . Zhang, W. W., Li, Y., Wang, X. Q., Tian, F., Cao, H., Wang, M. W., & Sun, Q. S. (2005). You also agree to receive emails from DrWeil.com, and you may opt Galectin-3 allows tumor cells to stick together, develop blood supply, metastasize and evade the immune system. Magnolol and honokiol achieve this effect by improving the intestinal movement that helps move digested food through the gastrointestinal tract. Research shows that both magnolol and honokiol are, by nature: The extract of the magnolia bark has been used for thousands of years in traditional Chinese and Japanese medicine. Neuropharmacology, 63(6), 11911199. But with proactive, natural stress management strategies, you can increase your resilience and receive lasting benefits for every area of health. Phellodendron is used for osteoarthritis, weight loss and obesity, diarrhea, ulcers in the stomach or upper part of the small intestine (peptic ulcers), diabetes, meningitis, pneumonia, eye infections, tuberculosis, and cirrhosis of the liver. Coping with stress is a full-time job, and your body needs all the support it can get. This article outlines an anti-inflammatory diet plan that is based on science. Traditional Chinese Medicine (TCM) is an ancient form of healthcare that dates 7 Natural Ways to Relieve Stress & Calm Down Your Anxiety, Stress Hormones: How Diet Affects Hormonal Balance, clinically researched modified citrus pectin (MCP), Frankincense Essential Oil Uses and Benefits for Healing, Oregano Oil Benefits for Infections, Fungus & Even the Common Cold, L-Glutamine Benefits Leaky Gut & Metabolism, Secret Detox Drink Recipe (A Natural Detox Drink Recipe), Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Symptoms of Candida Overgrowth & How to Get Rid of It, Investing in Your Grandkids Future? Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Among them, magnolol and honokiol are the main nutrients in magnolia bark with the most medicinal value. The supplement can be found at many online and retail stores. Magnolia bark has been used for centuries in traditional Chinese medicine to treat an array of conditions including depression, anxiety, and sleep issues like insomnia. A 24-week study in 89 menopausal women experiencing symptoms of sleep and mood alterations were given a supplement containing 60 mg of magnolia bark extract and 50 mg of magnesium daily. Nevertheless, magnolia bark appears to be a safe therapy that may help treat menopause symptoms. As far back as the 7th century, Magnolias were cultivated in the gardens of Chinese Buddhist temples. Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy. This study also supports previous research showing that regular meditation reduces other pro-cancer proteins like TNF-alpha and CRP these inflammatory markers are triggered by the master regulator, galectin-3. Christopher Hobbs, another well-known herbalist, also describes magnolia bark as supportive for inducing sleep. Stress can have a whirlwind effect on your emotions. In cancer, its a primary conductor. Retrieved from: https://www.christopherhobbs.com/webdocs/class-handouts/various/Healing-Sleep-Breitenbush.pdf, Hu, J., Chen, L. J., Liu, L., Chen, X., Chen, P. L., Yang, G., Hou, W. L., Tang, M. H., Zhang, F., Wang, X. H., Zhao, X., & Wei, Y. Q. Modern research shows that magnolia bark has anti-inflammatory, antioxidant, stress, and weight-reducing effects. Researchers found that MOE reduced evening cortisol levels, a stress marker, which led to a decrease in nighttime snacking. Related: Stress Hormones: How Diet Affects Hormonal Balance. A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. It is also commonly used to support gastrointestinal health. Magnolia bark extract is readily available in pill form. Today, you can also find this herb in the medical stores sold as bundles of 4 inches long magnolia bark strips. Researchers found that a combination of tumor radiation and honokiol had the capability to reduce a mouse lung tumor by 78%. The leaves and flowers from the tree are sometimes used as well. Other worthwhile measures include exercise, meditation, eliminating caffeine (from all sources), cognitive behavioral therapy, journaling and taking a news fast by avoiding the daily onslaught of (mostly bad) news online, on television and in newspapers and magazines. The magnolia is a deciduous tree that has multiple species that are native to eastern Asia, as well as the Americas. Journal of Zhejiang University. Kuribara, H., Kishi, E., Hattori, N., Okada, M., & Maruyama, Y. When we address galectin-3, we see enhanced results when we layer additional therapies that work synergistically with this approach. Scientific research also shows a strong connection between chronic stress and Alzheimers disease. Our team aims to be not only thorough with its research, but also objective and unbiased. While the stem barks are decocted to a slight extent in boiling water, the branch and root barks are dried in the shade. One recent clinical study published in the Journal of Clinical Oncologyshowed that this MCP effectively slowed PSA doubling time and cancer progression in patients with biochemical relapse of prostate cancer. In a mouse study, honokiol proved to elicit the anxiolytic effect in Hange-koboku-to and Saiboku-to, two medicines used in traditional Chinese medicine and Kampo (traditional Japanese medicine). Luckily, a large and fast-growing body of research has given us a specific therapeutic target to achieve this goal: the biological protein galectin-3. 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